Redox regulation of immunity and the role of small molecular weight thiols

It is thought that excessive production of reactive oxygen species (ROS) can be a causal component in many diseases, some which have an inflammatory component. This led to oversimplification whereby ROS are seen as and antioxidants anti-inflammatory. paper aims at reviewing the literature on thiols host defense. The review will first summarize mechanisms by we survive infections pathogens. Then consider how redox field evolved from concept oxidative stress regulation it intersects innate immunity. A third section analyze oversimplified theory disease hypothesis role glutathione (GSH) immunity, respectively pro- anti-inflammatory mediators. Finally, discuss recent research think out box link infection outlined section.